XWH - 09 - 1 - 0109 TITLE : Histone Code Modulation by Oncogenic PWWP - Domain Protein in Breast Cancers
نویسنده
چکیده
Oncogenic PWWP-domain protein WHSC1L1 links the homeobox transcription factor IRX3 in breast cancer” American Association for Cancer Research Annual Meeting in Washington, DC, April 17-21, 2010
منابع مشابه
Award Number : W 81 XWH - 09 - 1 - 0604 TITLE : Histone demethylase GASC 1 as a therapeutic target in basal breast cancer PRINCIPAL
متن کامل
A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.
The readout of histone modifications plays a critical role in chromatin-regulated processes. Dimethylation at Lys-36 on histone H3 (H3K36me2) is associated with actively transcribed genes, and global up-regulation of this modification is associated with several cancers. However, the molecular mechanism by which H3K36me2 is sensed and transduced to downstream biological outcomes remains unclear....
متن کامل